Immunoregulatory Functions of DOCK/STAT Complexes

Dr. Talal A. Chatila is the Denise and David Bunning Professor of Pediatrics at Harvard Medical School and a senior physician in the Division of Immunology at Boston Children’s Hospital. He also serves as the Director of the Food Allergy Program. His research focuses on the genetic and molecular mechanisms regulating immune tolerance, particularly the role of regulatory T (Treg) cells in allergic and autoimmune diseases.

Dr. Chatila’s work has been instrumental in identifying mutations in the Foxp3 transcription factor, which is critical for Treg cell function. His studies explore how Treg cell dysfunction leads to immune dysregulation, contributing to allergic inflammation and autoimmunity. He also investigates the reprogramming of Treg cells to restore immune balance, offering potential therapeutic strategies for Treg-related disorders. His research extends to understanding the mechanisms of tissue-specific immune tolerance in conditions like asthma and food allergies. Dr. Chatila combines cellular immunology, genomics, and transgenic animal models to develop precision therapies aimed at restoring immune homeostasis. His work continues to shape innovative treatments for allergic and autoimmune diseases.