The intersection of innate and adaptive immunity in the lung: implications for chronic pulmonary insufficiency

Dr. Sidonia Fagarasan is a Professor at Kyoto University’s Division of Integrated High-Order Regulatory Systems and Vice-Director of the Center for Cancer Immunotherapy and Immunobiology (CCII). She earned her M.D. from “Iuliu Hatieganu” University of Medicine & Pharmacy in Romania and later conducted research at Kyoto University. She has received multiple awards, including the Young Scientist Award (2005), the NISTEP Award (2013), and the 1st Kobayashi Award (2020).

Dr. Sidonia Fagarasan’s research explores mucosal immunity, focusing on the immune system’s role in regulating gut microbiota, mucosal barrier integrity, and systemic homeostasis. Her work has revealed the critical role of IgA antibodies, T cells, and key signaling receptors like PD-1 in maintaining gut-immune balance. She also studies how immune cell metabolites (SIMets) influence immune communication and how chronic immune activation affects brain biochemistry. Her findings aim to improve cancer immunotherapy by understanding checkpoint inhibitors.